张卫

职称：

教授

专业：

分析化学

博（硕）导：

博导

最终学历：

博士

联系电话：

0531-86182897

电子邮件：

zhangwei@sdnu.edu.cn

简历及研究领域

个人简介：

张卫，山东禹城人，博士，教授，博士生导师。2019年度山东省杰出青年基金获得者，全国黄大年式教学科研团队骨干成员, 2015年度山东省属高校优秀青年基金获得者。2012年毕业于南开大学化学37000cm威尼斯分析化学专业获博士学位，同年进入山东师范大学化学化工与材料科学37000cm威尼斯工作至今。主要从事仿生荧光传感材料的设计、制备及应用研究。针对复杂样品中目标蛋白质的定量分析问题，开展了一系列高灵敏的荧光检测方法研究，围绕细胞内重要的活性功能分子，发展了系列的荧光成像分析方法，取得了多项创新性和系统性的科研成果。在学术期刊发表论文40余篇，SCI他引2000余次，其中以第一或通讯作者发表在Angew. Chem. Int. Ed. 4篇，Chem. Sci. 2篇，Anal. Chem. 6篇。目前，主持国家自然科学基金面上项目2项，国家重点研发计划项目子课题1项，山东省杰出青年基金项目1项。2019年获得山东省自然科学奖二等奖。此外，张卫教授还曾获山东师范大学 “杰出青年”、山东师范大学优秀共产党员等荣誉称号。

代表性论文

(1) Jin Li, Na Zhao, Wei Zhang,* Ping Li, Xia Yin, Wen Zhang, Hui Wang, and Bo Tang*. Assessing the Progression of Early Atherosclerosis Mice Using a Fluorescence Nanosensor for the Simultaneous Detection and Imaging of pH and Phosphorylation. Angew. Chem. Int. Ed. 2023, 62, e202215178.

(2) Jun Lu, Zhongyao Jiang, Jie Ren, Wei Zhang*, Ping Li, Zhenzhen Chen, Wen Zhang, Hui Wang, and Bo Tang*. One-Pot Synthesis of Multifunctional Carbon-Based Nanoparticle-Supported Dispersed Cu²⁺ Disrupts Redox Homeostasis to Enhance CDT. Angew. Chem. Int. Ed. 2022, 61, e202114373. (Hot Paper)

(3) Wei Zhang, Jie Ren, Jun Lu, Ping Li, Wen Zhang, Hui Wang, and Bo Tang*. Elucidating the Relationship between ROS and Protein Phosphorylation through In Situ Fluorescence Imaging in the Pneumonia Mice. Anal. Chem., 2021, 93, 10907-10915.

(4) Wei Zhang, Xiaolei Liu, Ping Li, Wen Zhang, Hui Wang, and Bo Tang*. In   Situ Fluorescence Imaging of the Levels of Glycosylation and Phosphorylation by a MOF-Based Nanoprobe in Depressed Mice. Anal. Chem., 2020, 92, 3716-3721.

(5) Wei Zhang, Hui Zhang, Mengqi Wang, Ping Li, Caifeng Ding, Wen Zhang, Hui Wang, and Bo Tang*. Copolymer-Based Fluorescence Nanosensor for In Situ Imaging of Homocysteine in the Liver and Kidney of Diabetic Mice. Anal. Chem., 2020, 92, 16221-16228.

(6) Jiheng Xu,† Hui Zhang,† Wei Zhang*, Ping Li, Wen Zhang, Hui Wang and Bo Tang*. Fluorescence nanosensor for in situ detection of phosphate and alkaline phosphatase in parathyroid dysfunction mice. Chem. Commun., 2020, 56, 2431-2434.

(7) Wei Zhang, Xiaolei Liu, Ping Li, Wen Zhang, Hui Wang, Bo Tang* Cellular fluorescence imaging based on resonance energy transfer. TRAC-Trend. Anal. Chem. 2020, 123, 115742.

(8) Jun Lu, Li Yang, Wei Zhang,* Ping Li, Xiaonan Gao, Wen Zhang, Hui Wang and Bo Tang * Photodynamic therapy for hypoxic solid tumors via Mn-MOF as a photosensitizer. Chem. Commun., 2019, 55, 10792.

(9) Wei Zhang, Jun Lu, Xiaonan Gao, Ping Li*, Wen Zhang, Yu Ma, Hui Wang, Bo Tang*. Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained By Employing a Nano-MOF with CuII as Active Center. Angew. Chem. Int. Ed., 2018, 57, 4891-4896.

(10) Wei Zhang*, Ruixia Wang, Wei Liu, Xin Wang, Ping Li*, Wen Zhang, Hui Wang and Bo Tang*. Te-containing carbon dots for fluorescence imaging of superoxide anion in mice during acute strenuous exercise or emotional changes. Chem. Sci., 2018, 9, 721-727.

(11) Wei Zhang*, Jiheng Xu, Ping Li, Xiaonan Gao, Wen Zhang, Hui Wang and Bo Tang*. Treatment of hyperphosphatemia based on specific interaction between phosphorus and active center Zr(IV) of nano-MOFs. Chem. Sci., 2018, 9, 7483-7487.

(12) Wei Zhang, Junqing Kang, Ping Li*, Lu Liu, Hui Wang and Bo Tang*. Two-photon fluorescence imaging of sialylated glycans in vivo based on a sialic acid imprinted conjugated polymer nanoprobe. Chem. Commun., 2016, 52, 13991-13994.

(13) Wei Zhang, Junqing Kang, Ping Li*, Hui Wang, and Bo Tang*. Dual Signaling Molecule Sensor for Rapid Detection of Hydrogen Sulfide Based on Modified Tetraphenylethylene. Anal. Chem., 2015, 87, 8964-8969.

(14) Wei Zhang, Wei Liu, Ping Li*, Fang Huang, Hui Wang, and Bo Tang*. Rapid-Response Fluorescent Probe for Hydrogen Peroxide in Living Cells Based on Increased Polarity of C-B Bonds. Anal. Chem., 2015, 87, 9825-9828.

(15) Wei Zhang, Wei Liu, Ping Li*, Junqing Kang, Jiaoyang Wang, Hui Wang and Bo Tang*. Reversible two-photon fluorescent probe for imaging of hypochlorous acid in live cells and in vivo. Chem. Commun., 2015, 51, 10150-10153.

(16) Wei Zhang, Wei Liu, Ping Li*, Haibin Xiao, Hui Wang, and Bo Tang*. A Fluorescence Nanosensor for Glycoproteins with Activity Based on the Molecularly Imprinted Spatial Structure of the Target and Boronate Affinity. Angew. Chem. Int. Ed., 2014, 53, 12489-12493.

研究课题

国家自然科学基金面上项目：炎症风暴中ROS与蛋白质糖基化/磷酸化互作原位荧光成像

2021.01-2024.12，主持，在研

国家自然科学基金面上项目：细胞与活体中功能蛋白糖基化与磷酸化位点识别与互作实时原位荧光成像

2019.01-2022.12，主持，在研

山东省杰出青年基金：仿生荧光传感材料的设计、制备及应用研究

2019.07-2022.06，主持，在研

山东省属高校优秀青年人才联合基金项目：基于分子印迹技术的新型传感体系的构建及其在糖蛋白识别中的应用研究

2015.07-2016.12，主持, 已结题

山东省重点研发计划项目: 基于抗原决定基印迹技术的新型荧光纳米探针的制备及应用研究

2017.03-2019.03, 主持, 已结题

国家自然科学基金青年项目：用于非胁迫状态细胞中低浓度活性氧自由基检测的聚合物放大型荧光探针的设计与制备

2014.01-2016.12，主持, 已结题

山东省自然科学基金青年项目: 基于硼与糖蛋白特异性作用的分子印迹型荧光探针的制备及其应用研究

2013.10-2016.10, 主持, 已结题

荣誉称号

2019

山东省杰出青年基金获得者

2019

山东省自然科学二等奖

2019

山东师范大学安全文明先进个人

2018

山东师范大学优秀共产党员

2015

山东省属高校优秀青年基金获得者