陈蓁蓁

职称：

教授

专业：

分析化学

博（硕）导：

博士生导师

最终学历：

博士研究生

联系电话：

0531-86180861

电子邮件：

zzchen@sdnu.edu.cn

简历及研究领域

2001年获得理学硕士学位

2012年获得理学博士学位

2001年7月山东师范大学工作至今  

个人简介：

中共党员，教授。2013年斯坦福大学访问学者。《大学化学》杂志编委。主要研究领域为质谱分析，包括定量化学蛋白质组学及纸喷雾质谱分析。主持国家自然科学基金项目1项，山东省自然科学基金项目1项，山东省中青年科学家奖励基金项目1项，山东省教学改革重点项目2项。获山东省技术发明奖二等奖1项，山东省科学技术二等奖1项，山东省省级教学成果特等奖1项、一等奖2项，山东高等学校优秀科研成果二等奖2项，主讲的《分析化学》课程获得国家级一流课程认定，在国际学术期刊发表论文50余篇。

代表性论文

(1) Zhongyao Jiang, Yue Tang, Jun Lu, Chang Xu, Yaxin Ni, Guanglu Zhang, Yanmei Yang, Xiufen Cheng, Lili Tong, Zhenzhen Chen*, Bo Tang*, Identification of sulfhydryl-containing proteins and further evaluation of the selenium-tagged redox homeostasis-regulating proteins, Redox Biology, 2024, 69, 102969

(2) Yaxin Niu, Zhenzhen Chen,* Zhongyao Jiang, Yanmei Yang, Guangzhao Liu, Xiufen Cheng, Zhenhao Jiang, Guanglu Zhang, Lili Tong, and Bo Tang* Detection of Cysteine Sulfenic Acid on E. coli Proteins with a Biotin-Benzoboroxole Probe, ACS Chemical Biology, 2023, 18, 1351-1359

(3) Yanmei Yang, ‡ Weiqing Wang,‡ Zhenzhen Chen,* Xiaoxiao Wang, Xia Meng, Zhenhua Wang, Heping Jiao, Lili Tong, Bo Tang*，Highly sensitive quantification of ultratrace As(V) via iEESI-MS, Chemical Communication, 2023, 59, 9098 - 9101

(4) 姜中尧，牛雅新，王楠，陈蓁蓁*，唐波，基于蛋白质半胱氨酸的活性蛋白表达谱分析，大学化学, 2023, 1, 119 - 128

(5) Xiu-Fen Cheng, § Nan Wang, § Zhongyao Jiang, Zhenzhen Chen,* Yaxin Niu, Lili Tong, Ting Yu, and Bo Tang*，Quantitative Chemoproteomic Profiling of Targets of Au(I) Complexes by Competitive Activity-Based Protein Profiling, Bioconjugate Chemistry, 2022, 1131- 1137

(6) Xiu-Fen Cheng, § Ting Yu, § Yi Liu, Nan Wang, Zhenzhen Chen,* Guang-Lu Zhang, Lili Tong, and Bo Tang，Palladium(II)-Catalyzed C(sp2)-H Bond Activation/C-N Bond Cleavage Annulation of N-Methoxy Amides and Arynes, Organic Letters, 2022, 24, 2087 - 2092

(7) Yanmei Yang, Weiqing Wang, Huimin Liu, Lili Tong, Xiaoyan Mu, Zhenzhen Chen,* Bo Tang*, Sensitive Quantification of MicroRNA in Blood through Multiamplification Toehold- Mediated DNA-Strand-Displacement Paper Spray Mass Spectrometry (TSD-PS MS), Angewandte Chemie International Edition, 2022, 61, e202113051

(8) Zhenzhen Chen^#; Qian Shi^#; Weiqing Wang; Zhongyao Jiang; Guanglu Zhang; Lili Tong; Xiaoyan Mu; Bo Tang*; Fabrication of a “selenium signature” chemical probe-modified paper substrate for simultaneous and efficient determination of biothiols by paper spray mass spectrometry, Analytical Chemistry, 2021, 93: 1749-1756.

(9) Yanmei Yang;† Weihua Niu;† Weiqing Wang; Siyun Qi; Lili Tong; Xiaoyan Mu, Zhenzhen Chen;* Weifeng Li; Bo Tang*; h-FBN assisted negative ion paper spray for the sensitive detection of small molecules, Chemical Communication, 2021, 57, 6612

(10) Guang-Lu Zhang;† Minmin Zhang;† Qian Shi; Zhongyao Jiang; Lili Tong; Zhenzhen Chen;* and Bo Tang*; In Situ Construction of COF-Based Paper Serving as a Plasmonic Substrate for Enhanced PSI-MS Detection of Polycyclic Aromatic Hydrocarbons, ACS Applied Materials & Interfaces, 2021, 13, 43438-43448

(11) Yaxin Niu; Tong Ding; Junmin Liu; Guanglu Zhang; Lili Tong; Xiufen Cheng; Yanmei Yang; Zhenzhen Chen*; Bo Tang; Fluorescence switch of gold nanoclusters stabilized with bovine serum albumin for efficient and sensitive detection of cysteine and copper ion in mice with Alzheimer’s disease, Talanta, 2021, 223, 121745.

(12) Yanmei Yang; Junmin Liu; Zhenzhen Chen*; Weihua Niu; Ran Li; Le Niu; Peng Yang; Xiaoyan M; Bo Tang*; A High-Throughput Screening Method for Determining the Optimized Synthesis Conditions of Quinoxaline Derivatives Using Microdroplet Reaction, Frontiers in Chemistry. 2020, 8, 789.

(13) Guanglu Zhang^#; Tong Ding^#; Qian Shi; Zhongyao Jiang; Yaxin Niu; Minmin Zhang; Lili Tong; Zhenzhen Chen*; Bo Tang* Covalent organic frameworks-based paper solid phase microextraction combined with paper spray mass spectrometry for highly enhanced analysis of tetrabromobisphenol A, Analyst ,2020, 145, 6357-6362.

(14) Lili Tong^#; Xiuxiu Wang^#; Zhenzhen Chen; Yuhua Liang; Yapei Yang;Wen Gao; Zhenhua Liu;Bo Tang*; One-Step Fabrication of Functional Carbon Dots with 90% Fluorescence Quantum Yield for Long-Term Lysosome Imaging, Analytical Chemistry, 2020, 92, 6430-6436.

(15) 陈蓁蓁;杨燕美;姜中尧;唐波*;生命的神奇元素——硒. 大学化学, 2019, 34(12): 79-85.

(16) Yanmei Yang^#; Huimin Liu^#; Zhenzhen Chen*; Tianhong Wu; Zhongyao Jiang; Lili Tong; Bo Tang*; A simple 3D-printed enzyme reactor paper spray mass spectrometry platform for detecting BuChE activity in human serum, Analytical Chemistry, 2019, 91: 12874-12881.

(17) Lili Tong^#; Xiuxiu Wang^#; Wen Gao; Zhenhua Liu; Zhenzhen Chen; Guiying Cheng; Wenhua Cao; Meiju Sui; Bo Tang*; CeO₂ Nanowire-BODIPY-Adenosine Triphosphate Fluorescent Sensing Platform for Highly Specific and Sensitive Detection of Arsenate, Analytical Chemistry, 2018, 90, 14507-14513.

(18) Zhenzhen Chen^#; Zhongyao Jiang^#; Nan Chen^#; Qian Shi; Lili Tong; Fanpeng Kong; Xiufen Cheng; Hao Chen; Chu Wang*; Bo Tang*; Target discovery of ebselen with a biotinylated probe, Chemical Communication, 2018, 54: 9506-9509.

(19) Zhenzhen Chen^#; Yaxin Niu^#; Guiying Cheng; Lili Tong; Guanglu Zhang; Feng Cai; Tingting Chen; Bao Liu ; Bo Tang*;A fast, highly sensitive and selective assay of iodide ions with single-stranded DNA-templated copper nanoparticles as a fluorescent probe for its application in Kunming mice samples, Analyst, 2017, 142, 2781-2785.

(20) Lili Tong; Zhen-zhen Chen; Zhongyao Jiang; Miaomiao Sun; Lu Li; Ju Liu; Bo Tang* ; Fluorescent sensing of pyrophosphate anion in synovial fluid based on DNA-attached magnetic nanoparticles, Biosensors and Bioelectronics, 2015, 72, 51-55.

(21) Si Yang; Zhongyao Jiang; Zhenzhen Chen*; Lili Tong*; Jun Lu; Jiahui Wang; Bovine serum albumin-stabilized gold nanoclusters as a fluorescent probe for determination of ferrous ion in cerebrospinal fluids via the Fenton reaction, Microchimica Acta, 2015, 182, 1911-1916.

(22) Xiaolei Wang*; Jun Wang; Hongyan Fu; Dongju Liu; Zhenzhen Chen*; Determination of glutathione in single HepG2 cells by capillary electrophoresis with reduced graphene oxide modified microelectrode., Electrophoresis, 2014, 35(23):3371-8.

(23) Xiaolei Wang*; Lingjun Li; Zhongyi Li; Jun Wang; Hongyan Fu; Zhenzhen Chen*; Determination of ascorbic acid in individual liver cancer cells by capillaryelectrophoresis with a platinum nanoparticles modified electrode, Journal of Electroanalytical Chemistry, 2014, 712, 139–145.

(24) Lili Tong; Lu Li; Zhenzhen Chen; Qian Wang; Bo Tang*; Stable label-free fluorescent sensing of biothiols based on ThT direct inducing conformation-specific G-quadruplex, Biosensors and Bioelectronics, 2013, 49, 420-425.

(25) Zhenzhen Chen; Qingling Li; Qianqian Sun; Hao Chen; Xu Wang; Na Li; Miao Yin; Yanxia Xie; Hongmin Li; Bo Tang*, SimultaneousDetermination of Reactive Oxygen and Nitrogen Species in Mitochondrial Compartments of Apoptotic HepG2 Cells and PC12 Cells Based On Microchip Electrophoresis−Laser-Induced Fluorescence, Analytical Chemistry, 2012, 84, 4687−4694.

(26) Dongmei Chen; Zhenzhen Chen; Kehua Xu; Bo Tang*; Studies onthe supramolecular interaction between dimethomorph and disulfide linked β-cyclodextrindimer by spectrofluorimetry and its analytical application, J Agric. Food Chem.,2011, 59:4424-88.

(27) Zhenzhen Chen; Qingling Li; Xu Wang; Zhiyuan Wang; Ruirui Zhang; Miao Yin; Lingling Yin; Kehua Xu; Bo Tang *; Potent Methodfor the Simultaneous Determination of Glutathione and Hydrogen Peroxide inMitochondrial Compartments of Apoptotic Cells with MicrochipElectrophoresis-Laser Induced Fluorescence, Analytical Chemistry, 2010, 82: 2006–2012.

(28) Zhenzhen Chen; Ning Zhang; Linhai Zhuo; Bo Tang *; Catalytic kinetic methods for photometric or fluorometric determinationof heavy metal ions, Microchimica Acta, 2009, 164: 311-336.

(29) Lingling Yin; Zhenzhen Chen; Lili Tong; Kehua Xu; BoTang*; Progress on Fluorescent Probes for Thiols，Chinese J. Anal. Chem., 2009, 37:1073–1081.

(30) Bo Tang*; Lingling Yin; Xu Wang; Zhenzhen Chen; Lili Tong; Kehua Xu; A fast-response,highly sensitive and specific organoselenium fluorescent probe for thiols andits application in bioimaging, Chemical Communication, 2009, 35: 5293- 5295。

(31) BoTang*; Ning Zhang; Zhenzhen Chen; Kehua Xu; Linhai Zhuo; Liguo An; Guiwen Yang; Probing hydroxylradicals and their imaging in living cells by Use of FAM-DNA-Au nanoparticles, Chem. Eur. J .2007, 14: 522-528.

(32) Ning Zhang; Zhenzhen Chen; Bo Tang*; Recent applications of fluorescence imaging inbioanalysis, Chin. J. Anal. Chem., 2006, 34: 1030 -1034.

(33) Zhenzhen Chen; Ning Zhang; Wenshen Zhang; Bo Tang*; Progresses and applicationsof protein fluorescent probes, Chin. J. Anal. Chem., 2006, 34: 1341-1347.

(34) BoTang*; Zhenzhen Chen; NingZhang; Jie Zhang; Yan Wang; Synthesis and characterization of a novelcross-linking complex of beta-cyclodextrin-o-vanillin furfuralhydrazone andhighly selective spectrofluorimetric determination of trace gallium, Talanta, 2006, 68: 575-580.

研究课题

山东省自然科学基金面上项目, ZR2020MB098, 基于含硒化学探针对蛋白组半胱氨酸的活性探究及其在含硒类药物设计开发中的应用

2021-01至2023-12，主持

山东省优秀中青年科学家科研奖励基金计划项目, BS2013SW002, 基于微流控芯片的动脉血管微系统的构建及用于动脉粥样硬化的研究

2013-10至2016-10, 主持

国家自然科学基金青年项目, 21105057, 微流控芯片同时检测单细胞内多种自由基的研究

2012-01至2014-12, 主持

山东省自然科学奖二等奖：用于细胞内活性小分子检测的有机分子荧光探针研制及应用

山东省人民政府, 2014年

山东省技术发明奖二等奖：微流控芯片流体智能电动控制技术的研究与应用

山东省人民政府, 2011年

荣誉称号

山东师范大学教学名师

2021年

山东师范大学十佳优秀教师

2015年