董金环

职称：

副教授

专业：

有机化学

博（硕）导：

硕导

最终学历：

博士研究生

联系电话：

电子邮件：

dongjh@sdnu.edu.cn

简历及研究领域

个人简介：

2020.12-至今：山东师范大学，副教授

2019.11-2020.01：北京大学，访问学者

2017.09-2020.11：山东师范大学，讲师

2011.09-2017.07：东北师范大学,博士学位,有机合成

2007.09-2011.07：通化师范37000cm威尼斯，学士学位，化学

研究领域：异腈化学，有机氟化学及生物活性有机分子的合成研究。

招生信息：每年招收有机化学专业（有机合成化学研究方向）研究生2名。

代表性论文

1. Lan Bao, Min Li, Lianshun Zhang, Yating Xue, Jinhuan Dong,* and Xianxiu Xu*. Isocyanide Heterodimerization-Triggered Three-Component Reaction: Diversity-Oriented Synthesis of Quinoxalines. Org. Lett., 2023, DOI: 10.1021/acs.orglett.3c00794.

2. Xiaoyu Guo¹, Jinhuan Dong¹, Yunjie Zhu, Lan Bao, Zhongyan Hu, Xianxiu Xu.*Copper-catalyzed chemoselective heterocyclization of two isocyanides: facile access to pyrroloazepinone derivatives. Chin. Chem. Lett., 2023, 34, 107608–107611.

3. Lei Wang, Zitong Huang, Xiaoyu Guo, Jian Liu, Jinhuan Dong* and Xianxiu Xu.* Diastereodivergent synthesis of chromeno[2,3-b]chromenes by tuning all of the reactivity centers of isocyanoacetate. Chem. Commun., 2022, 58, 6433–6436.

4. Lan Bao, Yu Liu, Jinghan Peng, Yuan Wang, Jinhuan Dong,* and Xianxiu Xu.* Chemoselective Trimerization of Isocyanides: De Novo Synthesis of 2‑Indole-Substituted Quinolines and Pyridines. Org. Lett. 2022, 24, 105–109.

5. Jinhuan Dong,§ Junlin Hu,§ Xiaoli Liu, Shaoguang Sun,* Lan Bao, Mengying Jia,* and Xianxiu Xu.* Ionic Reactivity of 2‑Isocyanoaryl Thioethers: Access to 2‑Halo and 2‑Aminobenzothia/Selenazoles. J. Org. Chem. 2022, 87, 2845−2852.

6. Jinhuan Dong,‡ Wanzhong Feng,‡ Lei Wang, Mei Li, Zhe Chen,* and Xianxiu Xu.* Cu/Base Co-catalyzed [3 + 3] Cycloaddition for the Synthesis of Highly Functionalized 4-Fluoropyridines. Chem. Commun. 2021, 57, 12635–12638.

7. Xin Wang,† Jinhuan Dong,† Xianxiu Xu,* and Bo Tang.* Dinucleophilic Reactivity of Isocyanoacetate: Base-Catalyzed One-Pot Access to 4‑Azafluorenes and 4‑Azafluorenones. Org. Lett. 2021, 23, 9063−9067.

8. Jinhuan Dong,‡ Lei Wang,‡ Haoyue Li, Xinrong Leng, Xiaoyu Guo, Zhongyan Hu,* Xianxiu Xu.* Self-cyclization vs dimerization of o-alkenyl arylisocyanides: Chemodivergent synthesis of quinolines and pyrrolo-fused diindoles. Org. Chem. Front. 2021, 8, 2595–2600.

9. Jinhuan Dong, Mengying Jia, Xianxiu Xu.* Aryl groups, supplement of amino protecting group chemistry! Chin. Chem. Lett. 2021, 32, 1831–1833.

10. Jinhuan Dong, Dawei Zhang,* Yang Men, Xueming Zhang, Zhongyan Hu, Xianxiu Xu.* [1+2+3] Annulation as a General Access to Indolo[3,2-b]carbazoles: Synthesis of Malasseziazole C. Org. Lett. 2019, 21, 166–169.

11. Jinhuan Dong, Xin Wang, Hui Shi, Lei Wang, Zhongyan Hu,* Yifei Li, Xianxiu Xu.* Tandem Cyclization Annulation of a-Acidic Isocyanides with 2-Methyleneaminochalcones: Synthesis of Pyrrolo[2,3-c]quinoline Derivatives. Adv. Synth. Catal. 2019, 361, 863–867.

12. Jinhuan Dong, Lan Bao, Zhongyan Hu, Shenghua Ma, Xinyi Zhou, Mengru Hao, Ni Li, Xianxiu Xu.* Anion Relay Enabled [3+3]-Annulation of Active Methylene Isocyanides and Ene-Yne-Ketones. Org. Lett. 2018, 20, 1244–1247.

13. Lingjuan Zhang, Juanjuan Li, Zhongyan Hu, Jinhuan Dong,* XianMing Zhang, Xianxiu Xu.* Silver-Catalyzed Isocyanide Insertion into N-H Bond of Ammonia: [5+1] Annulation to Quinazoline Derivatives. Adv. Synth. Catal. 2018, 360, 1938–1942.

14. Ling Pan,# Jinhuan Dong,# Di Xie, Yifei Li, Qun Liu.* Synthesis of 2-(Trifluoromethyl)-dibenzopyranones with Rhodium(III)-catalyzed Formal anti-Michael Addition as Key Step. Adv. Synth. Catal. 2018, 360, 958–964.

15. Jinhuan Dong, Shuang Xin, Yanqing Wang, Ling Pan,* Qun Liu.* In-situ generation and reactions of p-(triuoromethyl)benzyl electrophiles: efficient access to p-(triuoromethyl)benzyl compounds. Chem. Commun. 2017, 53, 1668–1671.

16. Yang Men, Jinhuan Dong,* Shan Wang, Xianxiu Xu.* Bicyclization of Azomethine Ylide: Access to Highly Functionalized 3H-Pyrrolo[2,3-c]quinolones. Org. Lett. 2017, 19, 6712–6715.

17. Wei Yang,# Jinhuan Dong,# Jingyi Wang, Xianxiu Xu.* Rh(III)-Catalyzed Diastereoselective Annulation of Amides with Quinone Monoacetals: Access to Bridged Nine-Membered Heterocycles via C−H Activation. Org. Lett. 2017, 19, 616–619.

18. Jinhuan Dong, Lou Shi, Ling Pan,* Xianxiu Xu, Qun Liu.* 4-Trifluoromethyl-p-quinols as dielectrophiles: three-component, double nucleophilic addition/aromatization reactions. Sci. Rep. 2016, 6, 26957–26968.

19. Lin Zhang, Jinhuan Dong, Xianxiu Xu,* Qun Liu.* Chemistry of Ketene N,S-Acetals: An Overview. Chem. Rev. 2016, 116, 287–322.

20. Jinhuan Dong, Ling Pan,* Xianxiu Xu, Qun Liu.* a-Trifluoromethyl-(indol-3-yl)methanols as trifluoromethylated C3 1,3-dipoles: [3+2] cycloaddition for the synthesis of 1-(trifluoromethyl)-cyclopenta[b]indole alkaloids. Chem. Commun. 2014, 50, 14797–14800.

授权专利：

1. 徐显秀，门阳，胡忠燕，董金环，周心怡，郝梦如，李妮. 一种多取代咔唑衍生物及其制备方法.ZL201810224653.6

2.董金环，冯万忠，朱韵洁，徐显秀. 一种4-氟代吡啶衍生物及其制备方法和应用. ZL202110443506.X

3.徐显秀，王鑫，王淞，郭海洋，董金环. 一种4-氮杂芴类化合物及其制备方法和应用. ZL202110872482.X

4.徐显秀，宝兰，王源，董金环.一种喹啉联吲哚化合物及其制备方法和应用. ZL202111221086.7

研究课题

国家自然科学青年基金项目:基于1,3-偶极体接力策略构筑联杂环的研究

主持，2021.01－2023.12

山东省青年基金：烯炔酮及其类似物的[3+n]串联反应研究

主持，2019.07－2022.06

山东师范大学青年科技项目培育基金：烯炔酮与异腈的串联双环化反应研究

主持，2018.01－2020.01

东北师范大学重点实验室开放课题：烯炔酮的[3+n]环合反应研究

主持，2018.01－2018.11

东北师范大学重点实验室开放课题：基于新颖的呋喃-烯酮亚胺中间体的串联环化反应研究

主持，2019.01－2019.11

荣誉称号

山东省科学技术奖：基于新反应的杂环合成方法学研究

二等奖，5/5，2019.02

2019年山东师范大学优秀学士学位论文（设计）

指导教师，2019.06

2020年山东师范大学优秀学士学位论文（设计）

指导教师，2020.06

2021年山东师范大学优秀学士学位论文（设计）

指导教师，2021.06

2018-2019学年优秀班主任

2020-2021学年优秀班主任