王慧

职称：

副教授

专业：

化学工程与技术

博（硕）导：

博士生导师

最终学历：

博士研究生

联系电话：

电子邮件：

613006@sdnu.edu.cn

简历及研究领域

个人简介：

1、教育经历：

(1) 2010-09 至 2013-06, 南开大学, 微生物学, 博士

(2) 2008-06 至 2009-06, 悉尼大学, 应用科学, 硕士

(3) 2003-09 至 2007-06, 山东大学, 生物科学, 学士

2、学术工作经历：

(1) 2020 至 今,  山东师范大学, 化学化工与材料科学37000cm威尼斯,副教授，博士生导师

(2) 2019 至 2020, 新加坡国立大学，访问学者

(2) 2013 至 2019, 山东师范大学, 化学化工与材料科学37000cm威尼斯, 讲师

3、研究方向:

荧光探针设计合成及应用。通过利用荧光成像技术, 探索在疾病发生发展过程中，疾病相关物质的变化情况。

4、招生方向：

化学工程与技术学硕2名、分析化学2名、材料化工专硕1名。

5、承担课题：

(1) 国家自然科学基金面上项目,近红外荧光导航动脉粥样硬化诊疗一体化材料的设计、制备及应用, 2022-01-01 至 2025-12-31, 53万元, 在研, 主持；

(2) 国家自然科学基金青年项目,用于细胞与活体中超氧阴离子实时、原位动态监测的新型基因编码荧光探针的制备及应用, 2015-01-01 至 2017-12-31, 25万元, 结题, 主持;

(3) 国家自然科学基金重点项目,细胞与活体水平上氧化应激信号转导通路关联分子的实时原位成像, 2022-01-01 至 2026-12-31, 305万元, 在研, 参与；

(4) 山东省自然科学基金面上项目,高尔基体氧化应激与重大疾病之间的关键信号通路研究, 2021-01 至 2023-12, 10万元, 结题, 主持;

(5) 山东省自然科学基金重大基础研究项目,海洋绿色防污新技术及其杀菌防污机理研究, 2024-01 至 2026-12, 160万元, 在研, 参与;

(6) 山东省重点研发计划，利用快速、高灵敏度检测白三烯A4水解酶的荧光探针筛选新型抗癌药物，2016-03至 2018-03, 10万元, 结题, 主持;

代表性论文

(1) Prediction of Early Atherosclerotic Plaques Using a Sequence‐Activated Fluorescence Probe for the Simultaneous Detection of γ‐Glutamyl Transpeptidase and Hypobromous Acid. Hui Wang; Xiaoting Zhang; Ping Li; Fang Huang; Tiancong Xiu; HongTong Wang; Wei Zhang; Wen Zhang; Bo Tang. Angewandte Chemie International Edition, 2023, 136(1): e202315861

(2) Fluorescence probes for sensing and imaging within Golgi apparatus. Hui Wang; Xiaoting Zhang; Tiancong Xiu; Hongtong Wang; Ping Li; Bo Tang. Coordination Chemistry Reviews, 2023, 502: 215618

(3) Recent progress in the development of small-molecule double-locked logic gate fluorescence probes. Xiaoting Zhang; Tiancong Xiu; Hui Wang; Hongtong Wang; Ping Li; Bo Tang. Chemical Communications, 2023, 59: 11017-11027

(4) Treatment evaluation of Rheumatoid arthritis by in situ fluorescence imaging of the Golgi cysteine. Hui Wang; Na Wen; Ping Li; Tiancong Xiu; Shuqi Shang; Wei Zhang; Wen Zhang; Junnan Qiao; Bo Tang. Talanta, 2023, 270: 125532

(5) Exploring Idiopathic Pulmonary Fibrosis Biomarker by Simultaneous Two-Photon Fluorescence Imaging of Cysteine and Peroxynitrite. Hui Wang; Junwei Nie; Ping Li; Xiaoting Zhang; Yu Wang; Wei Zhang; Wen Zhang; Bo Tang. Analytical Chemistry, 2022, 94(32): 11272-11281

(6) Simultaneous fluorescence imaging of Golgi O₂ and Golgi H₂O₂ in mice with hypertension. Hui Wang; Cuifang Liu; Xiaoting Zhang; Tiancong Xiu; Ping Li; Wei Zhang; Wen Zhang; Xin Wang; Zhenzhen Liu; Bo Tang. Biosensors and Bioelectronics, 2022, 213: 114480-114480

(7) Evaluation of effectiveness of antiarthritic treatment by in situ ratiometric fluorescence imaging of the endoplasmic reticulum pH. Hui Wang; Xiaoting Zhang; Mingyan Dong; Wei Zhang; Wen Zhang; Ping Li; Bo Tang. Sensors and Actuators B: Chemical, 2021, 349: 130786

(8) A two-photon fluorescent probe for imaging of mitochondrial cysteine in λ-carrageenan induced arthritis. Hui Wang; Hongtong Wang; Xiaoting Zhang; Mingyan Dong; Fang Huang; Ping Li; Bo Tang. Sensors and Actuators B: Chemical, 2021, 338: 129749

(9) Dual-Colored Fluorescence Imaging of Mitochondrial HNO and Golgi-HNO in Mice with DILI. Hui Wang; Cuifang Liu; Zixu He; Ping Li; Wei Zhang; Wen Zhang; Bo Tang. Analytical Chemistry, 2021, 93(16): 6551

(10) Fluorescent probes for visualizing ROS-associated proteins in disease. Hui Wang; Xin Wang; Ping Li; Mingyan Dong; Shao Q. Yao; Bo Tang. Chemical Science, 2021, 12(35): 11620

(11) Ultrasensitive and ratiometric two-photon fluorescence imaging of Golgi polarity during drug-induced acute kidney injury. Hui Wang; Mingyan Dong; Hongtong Wang; Fang Huang; Ping Li; Wei Zhang; Wen Zhang; Bo Tang. Chemical Communications, 2021, 57(47): 5838

(12) In Situ Fluorescent and Photoacoustic Imaging of Golgi pH to Elucidate the Function of Transmembrane Protein 165. Hui Wang; Yuyun Yang; Fang Huang; Zixu He; Ping Li; Wei Zhang; Wen Zhang; Bo Tang. Analytical Chemistry, 2020, 4(92): 3103-3110

(13) Detection of microRNAs using toehold-initiated rolling circle amplification and fluorescence resonance energy transfer. Kaili Liang; Hui Wang; Ping Li; Youming Zhu; Ju Liu; Bo Tang. Talanta, 2020, 207: 120285

(14) Ratiometric fluorescence imaging of Golgi H2O2 reveals a correlation between Golgi oxidative stress and hypertension. Hui Wang; Zixu He; Yuyun Yang; Jiao Zhang; Wei Zhang; Wen Zhang; Ping Li; Bo Tang. Chemical Science, 2019, 47(10): 10876-10880.

(15) A photoacoustic and fluorescence dual-mode probe for LTA4H imaging reveals inflammation site in murine. Hui Wang; Ke Xue; Zhuwen Duan; Yuyun Yang; Zixu He; Chuanchen Wu; Wei Zhang; Wen Zhang; Ping Li; Bo Tang. Sensors and Actuators B: Chemical, 2019, 286: 243-249

(16) In situ photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis. Hui Wang; Yixin Zhang; Yuyun Yang; Zixu He; Chuanchen Wu; Wei Zhang; Wen Zhang; Ju Liu; Ping Li; Bo Tang. Chemical Communications, 2019, 65(55): 9685-9688.

(17) Fluorescent Imaging for Cysteine Detection In Vivo with High Selectivity. Zhuwen Duan; Youming Zhu; Yuyun Yang; Zixu He; Ju Liu; Ping Li; Hui Wang; Bo Tang. Chemistryopen, 2019, 3(8): 316-320

(18) In Vivo Two-Photon Fluorescence Imaging of the Activity of the Inflammatory Biomarker LTA4H in a Mouse Pneumonia Model. Hui Wang; Ke Xue; Ping Li; Yuyun Yang; Zixu He; Wei Zhang; Wen Zhang; Bo Tang. Analytical Chemistry, 2018, 90: 6020-6027

研究课题

国家自然科学基金面上项目

2021

国家自然科学基金青年项目

2014

山东省优秀中青年基金

2016

荣誉称号

东岳学者青年专家

2023