王栩

职称：

教授

招生专业：

分析化学（博士、硕士）；材料与化工（专硕）

博(硕)导：  

博导

最终学历：

博士

联系电话：

电子邮件：

wangxu@sdnu.edu.cn

简历及研究领域

个人简介：2000年7月于聊城大学化学化工37000cm威尼斯获理学学士学位，2003年7月于山东师范大学化学化工与材料科学37000cm威尼斯获理学硕士学位，2006年7月于中国科37000cm威尼斯生态环境研究中心获博士学位，2006年7月至2008年6月在清华大学化学系从事博士后研究。2008年9月进入山东师范大学化学化工与材料科学37000cm威尼斯工作。

主讲课程：《仪器分析化学》(本科专业基础课)、《现代光分析》(研究生必修课)，《分析化学实验》(本科必修课)

所获荣誉：曾获山东师范大学杰出青年、十佳优秀教师、校级优秀共产党员等荣誉，获校级研究生及本科生优秀教学奖。

研究领域：光学探针合成及其在细胞、小动物活体成像中的应用研究。主持完成国家自然科学面上及青年基金、山东省优秀中青年科学家科研奖励基金、教育部博士点基金青年教师基金等国家级、省部级项目多项，目前主持国家自然科学基金面上项目1项，先后参与国家自然科学基金重点项目、重大项目各1项。

招生专业：分析化学专业博士、硕士研究生；材料与化工专业学位硕士研究生

近期发表的主要论文

31. Xueyu Dou, Xu Wang*, Xilei Xie, Jian Zhang, Yong Li and Bo Tang*, Advances in Polymer-Based Organic Room-Temperature Phosphorescence Materials, Adv. Funct. Mater., 2024, 2314069

30. Jian Zhang, Jushuai Ma, Shuyue Zhang, Xiaoyan Lou, Yunshu Ding, Yong Li, Miaomiao Xu, Xilei Xie, Xiaoyun Jiao, Xueyu Dou, Xu Wang,* and Bo Tang*, Exploration of Thermally Activated Delayed Fluorescence (TADF)-Based Photoredox Catalyst To Establish the Mechanisms of Action for Photodynamic Therapy,         ACS Nano,   2023, 17, 23430-23441

29. Yong Li, Jiangong Zhang, Xiaolong Ni, Xu Wang,* Jian Zhang, Xilei Xie, Xueyu Dou, Xiaoyun Jiao, and Bo Tang *, Bioorthogonally Activatable Fluorescent Probe for Specific Imaging of Myeloid Cell Leukemia 1 Protein,  Anal. Chem., 2023, 95, 51, 18836–18843

28. Guangzhao Liu, Xilei Xie,* Yong Li, Jian Zhang, Xiaoyun Jiao, Xueyu Dou, Xu Wang*, and Bo Tang*, Responsive fluorescence probes for peroxynitrite: From design strategy to bioimaging applications, Trends in Analytical          Chemistry, 2023, 169, 117371

27. Xilei Xie, Jie Bian, Ye Song, Guangzhao Liu, Yuying Zhao, Jian Zhang, Yong Li, Xiaoyun Jiao, Xu Wang*, and Bo Tang*, In Situ Fluorescence Imaging Reveals Contribution of Cerebral Hydroxyl Radicals in Hyperhomocysteinemia-Induced Alzheimerlike Dementia, Anal. Chem., 2023, 95, 9872-9880

26. Jian Zhang, Yingying Xie, Jushuai Ma, Kaiqiang Liu, Yunshu Ding, Yong Li, Xiaoyun Jiao, Xilei Xie, Xu Wang* and Bo Tang*，Real-time visualization of the fluctuations in HOBr with AIE fluorescent probes during myocardial ischemia-reperfusion injury，Chem. Commun., 2023, 59, 1018-1021

25. Xilei Xie, Yawen Liu, Guangzhao Liu, Yuying Zhao, Jinyan Liu, Yong Li, Jian Zhang, Xiaoyun Jiao, Xu Wang* and Bo Tang*, Two-photon fluorescence imaging of the cerebral peroxynitrite stress in Alzheimer’s disease,                 Chem. Commun., 2022, 58, 6300-6303

24. Xilei Xie*, Yawen Liu, Guangzhao Liu, Yuying Zhao, Jie Bian, Yong Li, Jian Zhang, Xu Wang*, and Bo Tang*, Photocontrollable Flurescence Imaging of Mitochondrial Peroxynitrite during Ferroptosis with High Fidelity,             Anal. Chem., 2022, 94, 10213-10220

23. Jian Zhang, Jin Zhang, Xudong Teng, Xu Liu, Xiaoyun Jiao, Yong Li, Xilei Xie, Qiang Yan, Xu Wang*, and Bo Tang*, Fabricating and Modulating Robust Multi-Photoaddressable Systems with the Derivatives of Diarylethylene and Donor–Acceptor Stenhouse Adducts, J. Phys. Chem. Lett., 2022, 13, 3611-3620

22. Ran Zhang, Jian Zhang*, Xue Zhang, Jushuai Ma, Shaoshuai Wang, Yong Li, Xilei Xie, Xiaoyun Jiao, Xu Wang* and Bo Tang*, Cyano-substituted stilbene (CSS)-based conjugated polymers: photophysical properties exploration and applications in photodynamic therapy, Biomaterials, 2022, 291, 121885

21. Kaiqiang Liu, Jian Zhang*, Xinxin Li, Yingying Xie, Yong Li, Xu Wang*, Xiaoyun Jiao, Xilei Xie and Bo Tang*, Hypochlorous acid-activated two-photon fluorescent probe for evaluation of anticancer drug-induced cardiotoxicity and screening of antioxidant drugs, Org. Chem. Front., 2022, 9, 6795-6801

20. Xilei   Xie, Guangzhao Liu, Yaxin   Niu, Chenghui Xu, Yong Li, Jian Zhang, Xiaoyun Jiao, Xu Wang,* and Bo   Tang*, Dual-channel imaging of amyloid-β plaques and peroxynitrite to illuminate   their correlations in Alzheimer’s disease by a unimolecular two-photon   fluorescent probe, Anal. Chem. 2021, 93, 45, 15088-15095

19. Jian Zhang, Kaiqiang, Liu, Jingwen Li, Yingying   Xie, Yong Li, Xu Wang,* Xilei Xie, Xiaoyun Jiao, and Bo Tang*, Harnessing   Se=N to develop novel fluorescent probes for visualizing the variation of endogenous hypobromous acid (HOBr) during the administration of immunotherapeutic agent, Chem.   Commun., 2021, 57, 12679-12682

18. Jian   Zhang, Ran Zhang, Kaiqiang Liu, Yong Li, Xu Wang,* Xilei   Xie, Xiaoyun Jiao, and Bo Tang*, A light-activatable photosensitizer for photodynamic   therapy based on a diarylethene derivative, Chem.   Commun., 2021, 57, 8320-8323

17. Jinye Niu, Yong Li, Ran Zhang, Jian Zhang, Xu Wang,* Xilei Xie, Xiaoyun Jiao, Bo Tang*, A near-infrared fluorogenic   probe for nuclear thiophenol detection, Chem. Commun., 2021, 57, 2800-2803

16. Yong   Li, Yingzheng Shu, Xu Wang,* Xiaoyun Jiao, Xilei Xie, Jian Zhang and Bo Tang*, A H₂S-activated   Ratiometric CO Photoreleaser Enabled by Excimer/Monomer Conversion, Chem. Commun., 2019, 55,  6301-6304

15. Jian   Zhang, Muwen Liang, Xu Wang,* Yong Li, Xiaoyun Jiao, Xilei Xie, and Bo Tang*, Visualizing   Peroxynitrite Fluxes in Myocardial Cells by a New Fluorescent Probe Reveals   the Protective Effect of Estrogen,                 Chem. Commun., 2019, 55,   6719-6722

14.   Yong Li, Zhiwen Zhao, Yongsheng Xiao, Xu   Wang,* Xiaoyun Jiao, Xilei Xie, Jian Zhang and Bo Tang*,   Reactivity modulation of benzopyran-coumarin platform by introducing   electron-withdrawing groups: specific detection of biothiols and   peroxynitrite, Anal.Chem., 2019, 91, 6097-6102

13.   Xilei Xie,*, Guangzhao Liu, Xingxing Su, Yong Li, Yawen Liu, Xiaoyun Jiao, Xu Wang,* and Bo Tang*, A Facile, Versatile, and Highly Efficient   Strategy for Peroxynitrite Bioimaging Enabled by Formamide Deformylation,         Anal. Chem., 2019, 91,   6872-6879

12. Xilei   Xie, Tianhong Wu, Xu Wang,* Yong Li, Kaiye Wang, Zhiwen Zhao, Xiaoyun Jiao and Bo   Tang*, Two-photon fluorescent probe for ratiometric visualization of   hypochlorous acid in live cells and animals based on selenide   oxidation/elimination tandem reaction, Chem. Commun., 2018, 54, 11965-11968

11. Yong   Li, Yingzheng Shu, Muwen Liang, Xilei Xie, Xiaoyun Jiao, Xu   Wang*, and Bo Tang*, A Two-photon H₂O₂-activated   CO Photoreleaser, Angew. Chem. Int. Ed., 2018, 57, 12415-12419

10. Xilei   Xie*, Fuyan Tang, Guangzhao   Liu, Yong Li, Xingxing Su, Xiaoyun Jiao, Xu Wang*, and   Bo Tang*, Mitochondrial Peroxynitrite Mediates Anthracycline Induced   Cardiotoxicity as Visualized by a Two-Photon Near-Infrared Fluorescent Probe, Anal. Chem., 2018, 90,   11629-11635

9.   Xiaoyun Jiao, Yongsheng Xiao, Yong Li, Muwen Liang, Xilei Xie, Xu Wang* and Bo Tang*, Evaluating Drug-Induced Liver Injury and Its   Remission via Discrimination and Imaging of HClO and H2S with a Two-Photon   Fluorescent Probe, Anal. Chem., 2018, 90, 7510-7516

8. Xiaoyun Jiao, Yong Li, Jinye   Niu, Xilei Xie, Xu Wang^*, Bo Tang^*, Small-Molecule Fluorescent Probes for Imaging and Detection   of Reactive Oxygen, Nitrogen, and Sulfur Species in Biological Systems, Anal. Chem., 2018, 90,   533-555

7. Xilei Xie, Jilin Fan, Muwen Liang, Yong   Li, Xiaoyun Jiao, Xu Wang*, Bo Tang*, A two-photon   excitable and ratiometric fluorogenic nitric oxide photoreleaser and its   biological applications, Chem. Commun., 2017, 53, 11941   -11944

6. Yong Li, Xilei Xie, Xiu’e Yang, Mengmeng Li, Xiaoyun Jiao, Yuhui   Sun, Xu Wang* and Bo Tang*, Two-photon Fluorescent Probe for Revealing Drug-induced   Hepatotoxicity via Mapping Fluctuation of Peroxynitrite,  Chem. Sci., 2017, 8, 4006-4011

5. Xilei Xie, Fuyan Tang, Xiaoyan Shangguan, Shiyi Che, Jinye   Niu, Yongsheng Xiao, Xu Wang* and   Bo Tang*, Two-photon imaging of formaldehyde in live cells and animals   utilizing a lysosome-targetable and acidic pH-activatable fluorescent probe. Chem. Commun., 2017, 53,   6520-6523

4. Jinye Niu, Jilin Fan, Xu Wang*,  Yongsheng Xiao, Xilei Xie, Xiaoyun Jiao, Chuan-Zhi Sun, and Bo Tang*,   Simultaneous Fluorescence and Chemiluminescence Turned on by   Aggregation-Induced Emission for Real-time Monitoring of Endogenous   Superoxide Anion in Live Cells. Anal. Chem., 2017, 89, 7210-7215

3. Xilei Xie, Mengmeng Li, Fuyan Tang, Yong Li, Leilei Zhang,   Xiaoyun Jiao, Xu Wang,* and Bo Tang*, Combinatorial Strategy to Identify   Fluorescent Probes for Biothiol and Thiophenol Based on Diversified   Pyrimidine Moieties and Their Biological Applications, Anal. Chem., 2017, 89, 3015-3020

2. Xilei Xie, Xiu’e Yang, Tianhong Wu, Yong Li, Mengmeng Li,   Qi Tan, Xu Wang*, and Bo Tang*, Rational Design of an α-Ketoamide-Based   Near-Infrared Fluorescent ProbeSpecific for Hydrogen Peroxide in Living   Systems,          Anal. Chem., 2016, 88, 8019-8025

1. Yong Li, Xu Wang (共同一作), Jie Yang, Xilei Xie, Mengmeng Li, Jinye Niu, Lili Tong, and Bo Tang*, Fluorescent Probe Based onAzobenzene-Cyclopalladium for the Selective   Imaging of Endogenous CarbonMonoxide under Hypoxia Conditions, Anal. Chem., 2016, 88,  11154-11159

专利:

3. 唐波，王栩，李勇，解希雷，李萌萌，一种检测细胞内CO的荧光探针及其制备方法和应用，中国发明专利，ZL   201610069351.7

2. 唐波，王栩，孙娟，马晓旭，吕建政，一种检测细胞内硫化氢的荧光探针及其制备方法和应用，中国发明专利：ZL   201210504410.0

1.   林金明，王栩，魏彦林，环境水样在线自动检/监测的水样分配器，中国发明专利：ZL   200410096176.8

著 作：

《化学发光免疫分析》，编著 林金明，赵利霞，王 栩，化学工业出版社，2008年3月。