解希雷

职称：  

特聘教授

专业：  

分析化学

化学工程与技术

博(硕)导：  

博导/硕导

最终学历：  

博士研究生

联系电话：  

电子邮件：  

xiexilei@sdnu.edu.cn

个人简介：

2008年本科毕业于山东大学药37000cm威尼斯，2014年博士毕业于北京协和医37000cm威尼斯（清华大学医学部），2014年山东师范大学工作至今，2019-2020年新加坡南洋理工大学访问交流。

目前主要从事“荧光染料及分子诊疗试剂的设计合成与生物应用”相关研究工作，主持国家自然科学基金3项、山东省自然科学基金2项，在国际学术期刊发表研究论文30余篇，获授权国家发明专利5项，以主要完成人荣获山东省自然科学奖二等奖1项、中国药学会科学技术奖一等奖1项、中国分析测试协会科学技术奖二等奖1项，指导学生荣获全国大学生制药工程设计竞赛国家二等奖1项、三等奖1项，获山东省优秀青年基金资助，入选山东师范大学东岳学者青年人才，任山东省药学会高等药学教育专业委员会委员。

招生信息：

每年在分析化学/化学工程与技术专业招收硕士研究生2-3名。

代表性论文

(23) Guangzhao Liu, Xilei Xie^*, Yong Li, Jian Zhang, Xiaoyun Jiao, Xueyu Dou, Xu Wang^*, Bo Tang^*, Responsive fluorescence probes for peroxynitrite: design strategies, reaction mechanisms, and bioimaging applications, Trends in Analytical Chemistry, 2023, 169, 117371

(22) Xilei Xie^#, Jie Bian^#, Ye Song, Guangzhao Liu, Yuying Zhao, Jian Zhang, Yong Li, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, In situ fluorescence imaging reveals contribution of cerebral hydroxyl radicals in hyperhomocysteinemia-induced Alzheimer-like dementia, Analytical Chemistry, 2023, 95(26): 9872-9880

(21) Wenjun Yu^#, Xilei Xie^#, Yao Ma^#, Shiping Fang, Yi Dong^*, Gang Liu^*, Identification of 1,4-benzodiazepine-2,5-dione derivatives as potential protein synthesis inhibitors with highly potent anticancer activity, Journal of Medicinal Chemistry, 2022, 65(21): 14891-14915

(20) Xilei Xie^{*, #}, Yawen Liu^#, Guangzhao Liu, Yuying Zhao, Jie Bian, Yong Li, Jian Zhang, Xu Wang^*, Bo Tang^*, Photocontrollable fluorescence imaging of mitochondrial peroxynitrite during ferroptosis with high fidelity, Analytical Chemistry, 2022, 94(28): 10213-10220

(19) Xilei Xie, Yawen Liu, Guangzhao Liu, Yuying Zhao, Jinyan Liu, Yong Li, Jian Zhang, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, Two-photon fluorescence imaging of the cerebral peroxynitrite stress in Alzheimer’s disease, Chemical Communications, 2022, 58(43): 6300-6303

(18) Xilei Xie^#, Guangzhao Liu^#, Yaxin Niu, Chenghui Xu, Yong Li, Jian Zhang, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, Dual-channel imaging of amyloid-β plaques and peroxynitrite to illuminate their correlations in Alzheimer’s disease using a unimolecular two-photon fluorescent probe, Analytical Chemistry, 2021, 93(45): 15088-15095

(17) Yong Li^#, Yingzheng Shu^#, Xu Wang^*, Xiaoyun Jiao, Xilei Xie, Jian Zhang, Bo Tang^*, An H₂S-activated ratiometric CO photoreleaser enabled by excimer/monomer conversion, Chemical Communications, 2019, 55(44): 6301-6304

(16) Jian Zhang^#, Muwen Liang^#, Xu Wang^*, Yong Li, Xiaoyun Jiao, Xilei Xie, Bo Tang^*, Visualizing peroxynitrite fluxes in myocardial cells using a new fluorescent probe reveals the protective effect of estrogen, Chemical Communications, 2019, 55(47): 6719-6722

(15) Xilei Xie^{*, #}, Guangzhao Liu^#, Xingxing Su, Yong Li, Yawen Liu, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, A facile, versatile, and highly efficient strategy for peroxynitrite bioimaging enabled by formamide deformylation, Analytical Chemistry, 2019, 91(10): 6872-6879

(14) Yong Li^#, Zhiwen Zhao^#, Yongsheng Xiao, Xu Wang^*, Xiaoyun Jiao, Xilei Xie, Jian Zhang, Bo Tang^*, Reactivity modulation of benzopyran-coumarin platform by introducing electron-withdrawing groups: specific detection of biothiols and peroxynitrite, Analytical Chemistry, 2019, 91(9): 6097-6102

(13) Xilei Xie^#, Tianhong Wu^#, Xu Wang^*, Yong Li, Kaiye Wang, Zhiwen Zhao, Xiaoyun Jiao, Bo Tang^*, A two-photon fluorescent probe for ratiometric visualization of hypochlorous acid in live cells and animals based on a selenide oxidation/elimination tandem reaction, Chemical Communications, 2018, 54(84): 11965-11968

(12) Yong Li, Yingzheng Shu, Muwen Liang, Xilei Xie, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, A two-photon H₂O₂-activated CO photoreleaser, Angewandte Chemie International Edition, 2018, 57(38): 12415-12419

(11) Xilei Xie^{*, #}, Fuyan Tang^#, Guangzhao Liu, Yong Li, Xingxing Su, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, Mitochondrial peroxynitrite mediation of anthracycline-induced cardiotoxicity as visualized by a two-photon near-infrared fluorescent probe, Analytical Chemistry, 2018, 90(19): 11629-11635

(10) Xiaoyun Jiao^#, Yongsheng Xiao^#, Yong Li, Muwen Liang, Xilei Xie, Xu Wang^*, Bo Tang^*, Evaluating drug-induced liver injury and its remission via discrimination and imaging of HClO and H₂S with a two-photon fluorescent probe, Analytical Chemistry, 2018, 90(12): 7510-7516

(9) Xiaoyun Jiao, Yong Li, Jinye Niu, Xilei Xie, Xu Wang^*, Bo Tang^*, Small-molecule fluorescent probes for imaging and detection of reactive oxygen, nitrogen, and sulfur species in biological systems, Analytical Chemistry, 2018, 90(1): 533-555

(8) Xilei Xie^#, Jilin Fan^#, Muwen Liang, Yong Li, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, A two-photon excitable and ratiometric fluorogenic nitric oxide photoreleaser and its biological applications, Chemical Communications, 2017, 53(87): 11941-11944

(7) Xilei Xie^#, Fuyan Tang^#, Xiaoyan Shangguan, Shiyi Che, Jinye Niu, Yongsheng Xiao, Xu Wang^*, Bo Tang^*, Two-photon imaging of formaldehyde in live cells and animals utilizing a lysosome-targetable and acidic pH-activatable fluorescent probe, Chemical Communications, 2017, 53(48): 6520-6523

(6) Yong Li^#, Xilei Xie^#, Xiue Yang, Mengmeng Li, Xiaoyun Jiao, Yuhui Sun, Xu Wang^*, Bo Tang^*, Two-photon fluorescent probe for revealing drug-induced hepatotoxicity via mapping fluctuation of peroxynitrite, Chemical Science, 2017, 8(5): 4006-4011

(5) Xilei Xie, Mengmeng Li, Fuyan Tang, Yong Li, Leilei Zhang, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, Combinatorial strategy to identify fluorescent probes for biothiol and thiophenol based on diversified pyrimidine moieties and their biological applications, Analytical Chemistry, 2017, 89(5): 3015-3020

(4) Jinye Niu, Jilin Fan, Xu Wang^*, Yongsheng Xiao, Xilei Xie, Xiaoyun Jiao, Chuanzhi Sun, Bo Tang^*, Simultaneous Fluorescence and Chemiluminescence Turned on by Aggregation-Induced Emission for Real-time Monitoring of Endogenous Superoxide Anion in Live Cells, Analytical Chemistry, 2017, 89(13): 7210-7215

(3) Yong Li, Xu Wang^*, Jie Yang, Xilei Xie, Mengmeng Li, Jinye Niu, Lili Tong, Bo Tang^*, Fluorescent probe based on azobenzene-cyclopalladium for the selective imaging of endogenous carbon monoxide under hypoxia conditions, Analytical Chemistry, 2016, 88(22): 11154-11159

(2) Xilei Xie, Xiue Yang, Tianhong Wu, Yong Li, Mengmeng Li, Qi Tan, Xu Wang^*, Bo Tang^*, Rational design of an αketoamide-based near-infrared fluorescent probe specific for hydrogen peroxide in living systems, Analytical Chemistry, 2016, 88(16): 8019-8025

(1) Xilei Xie, Yu Yan, Ning Zhu, Gang Liu^*, Benzothiazoles exhibit broad-spectrum antitumor activity: their potency, structure–activity and structure–metabolism relationships, European Journal of Medicinal Chemistry, 2014, 76: 67-78

研究课题

国家自然科学基金面上项目

项目负责人，2024.01--2027.12

山东省自然科学基金优秀青年基金

项目负责人，2021.01--2023.12

国家自然科学基金面上项目

项目负责人，2019.01--2022.12

国家自然科学基金青年基金项目

项目负责人，2016.01--2018.12

山东省优秀中青年科学家科研奖励基金

项目负责人，2015.01--2016.12